Sì al vaccino contro l'HPV nelle donne HIV+ e HPV+

[Dora]

Uno studio dei National Institutes of Health dimostra che le donne HIV+ potrebbero trarre vantaggio dalla vaccinazione contro il papilloma virus, anche nel caso che siano già entrate in contatto con l'HPV.


HPV vaccine may benefit HIV-infected women

Women with HIV may benefit from a vaccine for human papillomavirus (HPV), despite having already been exposed to HPV, a study finds. Although many may have been exposed to less serious forms of HPV, more than 45 percent of sexually active young women who have acquired HIV appear never to have been exposed to the most common high-risk forms of HPV, according to the study from a National Institutes of Health research network.

HPV is the most common sexually transmitted infection in the world. The virus can infect the anal and genital areas, mouth and throat of males and females. High-risk forms of the virus can cause cancer, including cancer of the cervix.

The researchers noted that earlier studies had found many women with HIV were more likely than were women who did not have HIV to have conditions associated with HPV, such as precancerous conditions of the cervix, as well as for cervical cancer.

"Health care providers may hesitate to recommend HPV vaccines after a girl starts having sex," said study first author Jessica Kahn, M.D., M.P.H. of Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine. "However, our results show that for a significant number of young women, HPV vaccine can still offer benefits. This is especially important in light of their HIV status, which can make them even more vulnerable to HPV's effects."

The Centers for Disease Control and Prevention recommends HPV vaccination for girls ages 11-26. If an individual has not been exposed to the virus, approved HPV vaccines can protect against four types of the virus. Two HPV types, HPV-16 and HPV-18, cause 70 percent of cervical cancers. Two others, HPV-6 and HPV-11, cause 90 percent of genital warts.

At the time the women in the study received their first HPV vaccination, the researchers found that 12 percent had an existing HPV-16 infection and 5 percent had an HPV-18 infection. Because of their HIV status, these women may be more likely to develop cervical cancer or to develop a cancer that is hard to treat, the researchers said.

"Cervical cancer screening for sexually active young women is an important clinical priority, but our findings suggest it is especially so for women at risk of HIV," said study co-author Bill G. Kapogiannis, M.D., of the Pediatric, Adolescent and Maternal AIDS Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), one of six NIH institutes supporting the study.

Drs. Kahn and Kapogiannis conducted the research in collaboration with colleagues at the NICHD and Albert Einstein College of Medicine, New York City; Jefferson Medical College of Thomas Jefferson University, Philadelphia; New York University School of Medicine; Westat, Inc., Rockville, Md.; and the University of Alabama at Birmingham.

The research was conducted at a network of hospitals affiliated with the NICHD-funded Adolescent Medicine Trials Network for HIV/AIDS Interventions. Also supporting the study were the National Institute on Drug Abuse, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Cancer Institute and National Center for Research Resources.

The findings appear in the Journal of Acquired Immune Deficiency Syndromes.

The researchers analyzed blood and tissue samples from 99 HIV-positive women between 16 and 23 years old who were given an initial vaccination for HPV. The researchers examined the samples for evidence of an existing HPV infection as well as previous exposure to the virus.

The researchers tested for the presence of 41 of more than 100 existing types of HPV virus, including 13 high-risk types. They found that 75 percent of the women had an existing HPV infection with at least one type, with 54 percent testing positive for a high-risk type. However, when examining the two types that cause 70 percent of cervical cancers (HPV-16 and HPV-18), the researchers found that nearly half of the women had no existing infection with either type and showed no evidence of exposure to them.

When the researchers tested for each type of HPV individually, they found that nearly 75 percent of the women had no current HPV-18 infection and no evidence of previous exposure. For HPV-16, 56 percent did not have a current infection or previous exposure.

"Even among women who test positive for one type of HPV, the vaccine may effectively prevent infection with others — especially high-risk forms that cause cancer," Dr. Kahn said. "It’s important that doctors don't withhold the vaccine in these cases, thinking that it's too late for a vaccine to be effective." (...)



Abstract: Prevalence and Risk Factors for HPV in HIV-Positive Young Women Receiving Their First HPV Vaccination

[Eilan]

Direi che per me è una buona notizia, grazie Dora, fra poco ho la visita e proverò a parlargliene alla mia dottoressa, anche perchè nonostante le cure, colposcopie e biopsie ogni 6 mesi, a me la displasia non sta affatto regredendo.
Anni fa quando uscì il vaccino ne parlai con i miei dottori di allora e mi dissero che avendolo già contratto per me era inutile, mentre ora da questo studio non sembra sia proprio così inutile... magari sarebbe un bel pensiero in meno.

[cesar78]

è una bella notizia, ma dovrebbero mettersi d'accordo i medici... a noi è stato detto che il vaccino nei casi HPV+ è inutile, se non dannoso... mah...staremo a vedere.

[Dora]

Scusate, Melisanda e Cesar, se non sono più intervenuta. Ma volevo controllare se sia corretta l'idea che io ho tratto dall'abstract di questo studio degli NIH: che fare la vaccinazione in persone (perché, poi, solo donne?!) con HIV e HPV abbia senso se e solo se queste risultano negative ai ceppi di HPV contro i quali il vaccino è attivo.
Non ho ancora avuto il tempo di farlo.

Invece, ieri mi è arrivata via Nadir una notizia che ora trovo confermata in Quotidiano ER, il sito che dà notizie dall'Assemblea legislativa della Regione Emilia Romagna:

• In Emilia Romagna c'è ora la possibilità, per i ragazzi fino ai 26 anni e per le donne fino ai 45, di effettuare la vaccinazione HPV. Le spese sono totalmente a carico degli interessati, tranne che per persone con HIV, che hanno accesso gratuito al vaccino.

[Eilan]

Sai cosa? Mi è sembrato strano che in ginecologia non me lo abbiano proposto, eppure sanno mah vedremo ora mi vogliono rivedere fra alcuni mesi, e sicuramente questa cosa io me la ricorderò! A meno che non abbia ragione tu e sia solo per chi risulta negativa ai ceppi ad alto rischio, quindi se così fosse, io sarei comunque fuori.